"Consumption of mold-ripened food rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases"
Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food. Mol Nutr Food Res. 2008 Jul 21. [Epub ahead of print] Pócsi I, Jeney V, Kertai P, Pócsi I, Emri T, Gyémánt G, Fésüs L, Balla J, Balla G. Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
Iron-mediated oxidation of low-density lipoprotein has been implicated in the pathogenesis of vascular disorders such as atherosclerosis. The present investigations were performed to test whether hydrophobic fungal siderophores - hexadentate trihydroxamates desferricoprogen, desferrichrome, desferrirubin, and desferrichrysin - might suppress heme-catalyzed LDL oxidation and the toxic effects of heme-treated LDL on vascular endothelium. Indeed, two of these - desferricoprogen and desferrichrome - markedly increased the resistance of LDL to heme- catalyzed oxidation. In similar dose-response fashion, these siderophores also inhibited the generation of LDL products cytotoxic to human vascular endothelium. When iron-free fungal siderophores were added to LDL/heme oxidation reactions, the product failed to induce heme oxygenase-1, a surrogate marker for the noncytocidal effects of oxidized LDL (not in the case of desferrichrysin). Desferricoprogen also hindered the iron-mediated peroxidation of lipids from human atherosclerotic soft plaques in vitro, and was taken up in the gastrointestinal tract of rat. The absorbed siderophore was accumulated in the liver and was secreted in its iron-complexed form in the feces and urine. The consumption of mold-ripened food products such as aged cheeses and the introduction of functional foods and food additives rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases.
> "Consumption of mold-ripened food rich in fungal iron chelators in > diets may lower the risk of cardiovascular diseases"
> Fungal siderophores function as protective agents of LDL oxidation and > are promising anti-atherosclerotic metabolites in functional food. > Mol Nutr Food Res. 2008 Jul 21. [Epub ahead of print] > Pócsi I, Jeney V, Kertai P, Pócsi I, Emri T, Gyémánt G, Fésüs L, Balla > J, Balla G. > Department of Microbial Biotechnology and Cell Biology, Faculty of > Science and Technology, University of Debrecen, Debrecen, Hungary.
> Iron-mediated oxidation of low-density lipoprotein has been implicated > in the pathogenesis of vascular disorders such as atherosclerosis. > The present investigations were performed to test whether hydrophobic > fungal siderophores - hexadentate trihydroxamates desferricoprogen, > desferrichrome, desferrirubin, and desferrichrysin - might suppress > heme-catalyzed LDL oxidation and the toxic effects of heme-treated LDL > on vascular endothelium. Indeed, two of these - desferricoprogen and > desferrichrome - markedly increased the resistance of LDL to heme- > catalyzed oxidation. > In similar dose-response fashion, these siderophores also inhibited > the generation of LDL products cytotoxic to human vascular > endothelium. > When iron-free fungal siderophores were added to LDL/heme oxidation > reactions, the product failed to induce heme oxygenase-1, a surrogate > marker for the noncytocidal effects of oxidized LDL (not in the case > of desferrichrysin). > Desferricoprogen also hindered the iron-mediated peroxidation of > lipids from human atherosclerotic soft plaques in vitro, and was taken > up in the gastrointestinal tract of rat. > The absorbed siderophore was accumulated in the liver and was secreted > in its iron-complexed form in the feces and urine. > The consumption of mold-ripened food products such as aged cheeses and > the introduction of functional foods and food additives rich in fungal > iron chelators in diets may lower the risk of cardiovascular diseases.
On Aug 3, 5:11 am, ironjustice <ironjust...@lol.com> wrote: Tom <<
Looks like I have another .. nutbar .. following my posts ..
Meet ironjustice .. who obviously .. would have NOTHING to say .. unless .. **I** am .. here.
I .. define .. him ..
I .. am his reason .. for .. BEING ..
I wonder if that part .. sinks .. in ..
Heh .. heh ..
"Consumption of mold-ripened food rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases"
Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food. Mol Nutr Food Res. 2008 Jul 21. [Epub ahead of print] Pócsi I, Jeney V, Kertai P, Pócsi I, Emri T, Gyémánt G, Fésüs L, Balla J, Balla G. Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
Iron-mediated oxidation of low-density lipoprotein has been implicated in the pathogenesis of vascular disorders such as atherosclerosis. The present investigations were performed to test whether hydrophobic fungal siderophores - hexadentate trihydroxamates desferricoprogen, desferrichrome, desferrirubin, and desferrichrysin - might suppress heme-catalyzed LDL oxidation and the toxic effects of heme-treated LDL on vascular endothelium. Indeed, two of these - desferricoprogen and desferrichrome - markedly increased the resistance of LDL to heme- catalyzed oxidation. In similar dose-response fashion, these siderophores also inhibited the generation of LDL products cytotoxic to human vascular endothelium. When iron-free fungal siderophores were added to LDL/heme oxidation reactions, the product failed to induce heme oxygenase-1, a surrogate marker for the noncytocidal effects of oxidized LDL (not in the case of desferrichrysin). Desferricoprogen also hindered the iron-mediated peroxidation of lipids from human atherosclerotic soft plaques in vitro, and was taken up in the gastrointestinal tract of rat. The absorbed siderophore was accumulated in the liver and was secreted in its iron-complexed form in the feces and urine. The consumption of mold-ripened food products such as aged cheeses and the introduction of functional foods and food additives rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases.
> On Aug 3, 5:11 am, ironjustice <ironjust...@lol.com> wrote: Tom <<
> Looks like I have another .. nutbar .. following my posts ..
> Meet ironjustice .. who obviously .. would have NOTHING to say .. > unless .. **I** am .. here.
> I .. define .. him ..
> I .. am his reason .. for .. BEING ..
> I wonder if that part .. sinks .. in ..
> Heh .. heh ..
Tom Hennessy, also known as ironjustice, watchman, and several other past identities, is what might be called a 'single issue' fanatic. Be very wary of this persistent newsgroup abuser. He has been trolling many support newsgroups for several years. Tom Hennessy believes that excess iron is the cause of all diseases. When challenged, Tom often becomes verbally abusive including scatological and obscene language. He will not leave people with serious diseases like multiple sclerosis, heart disease, cancer and AIDS alone. He feels justified in cross-posting his rants to multiple support groups and becomes very rude and irrational if challenged.
> > On Aug 3, 5:11 am, ironjustice <ironjust...@lol.com> wrote: Tom <<
> > Looks like I have another .. nutbar .. following my posts ..
> > Meet ironjustice .. who obviously .. would have NOTHING to say .. > > unless .. **I** am .. here.
> > I .. define .. him ..
> > I .. am his reason .. for .. BEING ..
> > I wonder if that part .. sinks .. in ..
> > Heh .. heh ..
> Tom Hennessy, also known as ironjustice, watchman, and several other > past identities, is what might be called a 'single issue' fanatic. Be > very wary of this persistent newsgroup abuser. He has been trolling many > support newsgroups for several years. Tom Hennessy believes that excess > iron is the cause of all diseases. When challenged, Tom often becomes > verbally abusive including scatological and obscene language. He will > not leave people with serious diseases like multiple sclerosis, heart > disease, cancer and AIDS alone. He feels justified in cross-posting his > rants to multiple support groups and becomes very rude and irrational if > challenged.
"Consumption of mold-ripened food rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases"
Fungal siderophores function as protective agents of LDL oxidation and are promising anti-atherosclerotic metabolites in functional food. Mol Nutr Food Res. 2008 Jul 21. [Epub ahead of print] Pócsi I, Jeney V, Kertai P, Pócsi I, Emri T, Gyémánt G, Fésüs L, Balla J, Balla G. Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
Iron-mediated oxidation of low-density lipoprotein has been implicated in the pathogenesis of vascular disorders such as atherosclerosis. The present investigations were performed to test whether hydrophobic fungal siderophores - hexadentate trihydroxamates desferricoprogen, desferrichrome, desferrirubin, and desferrichrysin - might suppress heme-catalyzed LDL oxidation and the toxic effects of heme-treated LDL on vascular endothelium. Indeed, two of these - desferricoprogen and desferrichrome - markedly increased the resistance of LDL to heme- catalyzed oxidation. In similar dose-response fashion, these siderophores also inhibited the generation of LDL products cytotoxic to human vascular endothelium. When iron-free fungal siderophores were added to LDL/heme oxidation reactions, the product failed to induce heme oxygenase-1, a surrogate marker for the noncytocidal effects of oxidized LDL (not in the case of desferrichrysin). Desferricoprogen also hindered the iron-mediated peroxidation of lipids from human atherosclerotic soft plaques in vitro, and was taken up in the gastrointestinal tract of rat. The absorbed siderophore was accumulated in the liver and was secreted in its iron-complexed form in the feces and urine. The consumption of mold-ripened food products such as aged cheeses and the introduction of functional foods and food additives rich in fungal iron chelators in diets may lower the risk of cardiovascular diseases.
> Take your .. faq .. and faq .. off .. you little btch ..
Do I detect a bit of hostility there? :-)
I thought you liked the Kook Faq, Tommy. You've been posting the url quite a bit lately, so you must believe that it is a reliable source of information.
Come on now. Be honest with yourself. You know you've earned this. Might as well wear it as a badge of honor.
Or you can stop being such a dick. It's no sin to be a little obsessed with something you think is important, but you have been overdoing it and making a nuisance of yourself for many years now. All of this crossposting and hostility from you is not effective in educating the public about your favorite issue. All you do is piss people off. Why don't you get your web site going again? Start a blog? Write a book? Do something that isn't quite so lame.
